Past Publications

Here at CVICU we have a very active research team.

CVICU has a strong research interest with links to the Clinical Trials Group of the Australian and New Zealand Intensive Care Society (ANZICS), the Australian and New Zealand Intensive Care Research Centre, and the Medical Research Institute of New Zealand. 

The unit participates in multi-centre & multi-national clinical trials that we believe will benefit both our patients and the advancement of knowledge in Intensive Care Medicine.

List of Past Publications:


2009 H1N1 Pandemic

The ANZIC Influenza Investigators. Critical Care Services and 2009 H1N1 Influenza in Australia and NZ. New England Journal of Medicine. 2009;361(20): 1925-34

The Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators. Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. Journal of the American Medical Association. 2009;302(17): 1888-95

The ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System. Critical illness due to 2009 H1N1 influenza in pregnant and postpartum women. British Medical Journal. 2010;340:c1279

Knight M, Pierce M, Seppelt I, Kurinczuk JJ, Spark P, Brocklehurst P, McLintock C, Sullivan E; UK's Obstetric Surveillance System, the ANZIC Influenza Investigators, Australasian Maternity Outcomes Surveillance System. Critical illness with H1N1 influenza in pregnancy: a comparison of two population-based cohorts. British Journal of Obstetrics and Gynaecology. 2011;118(2):232-9

Nair P, Davies AR, Beca J, Bellomo R, Ellwood D, Forrest P, Jackson A, Pye R, Seppelt I, Sullivan E, Webb S. ECMO in Pregancy During 2009 H1N1 Pandemic. Intensive Care Medicine. 2011;37(4):648-54

Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherall M, Webb S, Beasley R; HEAT Investigators.; Australian and New Zealand Intensive Care Society Clinical Trials Group. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.New England Journal of Medicine. 2015;373(23):2215-24

Other ECMo

Shekar K, Roberts JA, Welch S, Buscher H, Rudham S, Burrows F, Ghassabian S, Wallis SC, Levkovich B, Pellegrino V, McGuinness S, Parke R, Gilder E, Barnett AG, Walsham J, Mullany DV, Fung YL, Smith MT, Fraser JF. ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during ExtracorporealMembrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiol. 2012;12:29


Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O'Donoghue S, Simpson N, Young P; DahLIA Investigators; Australian and New Zealand Intensive Care Society ClinicalTrials Group. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. JAMA. 2016;315(14):1460-8.

Fluid Management

McGuinness S, Parke R. Using cardiac output monitoring to guide perioperative haemodynamic therapy. Curr Opin Crit Care. 2015;21(4):364-8

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial. JAMA. 2015 Oct 27;314(16):1701-10.

Parke RL, McGuinness SP, Gilder E, McCarthy LW, Cowdrey KA.A randomised feasibility study to assess a novel strategy to rationalise fluid in patients after cardiac surgery. Br J Anaesth. 2015;115(1):45-52.

Eastwood GM, Parke R, Peck L, Young H, Paton E, Zhang L, Zhu G, Tanaka A, Glassford NJ, Bellomo R. Intravenous fluid bolus therapy: a bi-national survey of critical care nurses' self-reported practice. Anaesth Intensive Care. 2016; 44(1):44-51.

Parke RL, McGuinness SP, Gilder E, McCarthy LW. Intravenous fluid use after cardiac surgery A multicentre, prospective, observational study. Crit Care Resusc. 2014;16(3):164-9.

High Flow Nasal Prongs

High flow nasal oxygen therapy in patients after cardiac surgery. Rachael Parke's Thesis 2014

Parke RL, Bloch A, McGuinness SP. Effect of Very-High-Flow Nasal Therapy on Airway Pressure and End-Expiratory Lung Impedance in Healthy Volunteers. Respir Care. 2015;60(10):1397-403.

Rachael L. Parke1, Shay P. McGuinness, David Milne, and Andrew Jull. A new system for assessing atelectasis on chest x-ray after sternotomy for cardiac surgery. Medical Imaging and Radiology. 2014

Parke R, McGuinness S, Eccleston M. Nasal high-flow therapy delivers low level positive airway pressure. Br J Anaesth. 2009;103(6):886-90.

Parke R, McGuinness S, Dixon R, Jull A. Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients. Br J Anaesth. 2013;111(6):925-31.

Parke RL, Eastwood GM, McGuinness SP; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Oxygen therapy in non-intubated adult intensive care patients a point prevalence study. Crit Care Resusc. 2013;15(4):287-93.

Parke RL, McGuinness SP. Pressures Delivered By Nasal High Flow Oxygen During All Phases of the Respiratory Cycle. Respir Care. 2013;58(10):1621-4.

Parke RL, Eccleston ML, McGuinness SP. The effects of flow on airway pressure during nasal high-flow oxygen therapy. Respir Care. 2011;56(8):1151-5.

Parke RL, McGuinness SP, Dixon R, Jull A. Protocol for a randomised controlled trial of nasal high flow oxygen therapy compared to standard care in patients following cardiac surgery: the HOT-AS study. Int J Nurs Stud. 2012;49(3):338-44.

Parke RL, McGuinness SP, Eccleston ML. A Preliminary Randomized Controlled Trial to Assess Effectiveness of Nasal High-Flow Oxygen in Intensive Care Patients. Respir Care. 2011;56(3):265-70.

Hyperoxia and Cardiopulmonary Bypass

McGuinness SP, Parke RL, Drummond K, Willcox T, Bailey M, Kruger C, Baker M, Cowdrey KA, Gilder E, McCarthy L, Painter T; SO-COOL investigators. A Multicenter, Randomized, Controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary Bypass. Anesthesiology. 2016;125(3):465-73.

Nutrition Studies

Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, Harrigan PW; Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults. Lancet Respir Med. 2015;3(12):943-52.

Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, Harrigan PW; Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlledtrial. Lancet Respir Med. 2015;3(12):943-52.

Renal Trails

RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009 22;361(17):1627-38.

Fanning N, Galvin S, Parke R, Gilroy J, Bellomo R, McGuinness S. A Prospective Study of the Timing and Accuracy of Neutrophil Gelatinase-Associated Lipocalin Levels in Predicting Acute Kidney Injury in High-Risk Cardiac Surgery Patients. J Cardiothorac Vasc Anesth. 2016;30(1):76-81.

Bailey M, McGuinness S, Haase M, Haase-Fielitz A, Parke R, Hodgson CL, Forbes A, Bagshaw SM, Bellomo R. Sodium bicarbonate and renal function after cardiac surgery: a prospectively planned individual patient meta-analysis. Anesthesiology. 2015;122(2):294-306.

McGuinness SP, Parke RL, Bellomo R, Van Haren FM, Bailey M. Sodium Bicarbonate Infusion to Reduce Cardiac Surgery–Associated Acute Kidney Injury: A Phase II Multicenter Double-Blind Randomized Controlled Trial. Crit Care Med. 2013;41(7):1599-607.

Gallagher M, Cass A, Bellomo R, Finfer S, Gattas D, Lee J, Lo S, McGuinness S, Myburgh J, Parke R, Rajbhandari D; POST-RENAL Study Investigators and the ANZICS Clinical Trials Group. Long term survival and dialysis dependency following acute kidney injury in intensive care extended follow-up of a randomized controlled trial. PLoS Med. 2014;11(2):e1001601


Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, Wallace S; ATACAS Investigators of the ANZCA Clinical Trials Network. Stopping vs. Continuing Aspirin before Coronary Artery Surgery. N Engl J Med. 2016;374(8):728-37

Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, McGuinness S, Byrne K, Chan MT, Landoni G, Wallace S; ATACAS Investigators of the ANZCA Clinical Trials Network. Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. N Engl J Med. 2017;376(2):136-148.

Rose L, Baldwin I, Crawford T, Parke R. Semirecumbent positioning in ventilator dependent patients a multicenter observational study. Am J Crit Care. 2010 Nov;19(6):e100-8.

Hodgson CL, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Gabbe B, Harrold M, Higgins A, Iwashyna TJ, Papworth R, Parke R, Patman S, Presneill J, Saxena M, Skinner E, Tipping C, Young P, Webb S; Trial of Early Activity and Mobilization Study Investigators.A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-DirectedMobilization in the ICU. Crit Care Med. 2016;44(6):1145-52.